Blocker

In the immune double-antibody sandwich reaction, some antibodies exist in certain test samples that can bind to antibodies from different species, thus often leading to incorrect test results.

Categories: Blocker, Reagent

Description
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Common interfering factors include: 1. Interference from heterophilic antibodies; 2. Interference from rheumatoid factors.

Among these, alloantibody interference refers to the situation where a specific antibody from a certain type of animal can bind specifically and cause incorrect results. The most common alloantibody is HAMA (Human Anti-mouse Anubody) antibody. The interference reaction caused by this type of antibody often occurs in immune tests and its occurrence rate is around 10%. For example, if someone has been exposed to or has received it before, there will be human antibodies against mice in their body.

Application: Applying the blocking agent in appropriate amounts onto the sample pad and allowing it to fully mix with the sample can eliminate false positive results.